May 09

LGC supports science, innovation, research, analysis and…“This Morning”

LGC is a world leader in forensic science and the UK’s leading full service forensics provider.

We offer a comprehensive range of forensic science services, based on an extensive range of techniques and serve the police, crime enforcement agencies and an increasing number of private sector clients.

In order to highlight the role that forensic science can play in solving crime we have been working with ITV’s This Morning show, as part of ‘Crime Week’ (in November 2012 and April 2013).

Our first collaboration covered Blood Pattern Analysis (BPA) – particularly cast off and voids – protein stains, chemical development, footwear marks for intelligence and evidential purposes, presumptive test for drugs of abuse and cutting agents, and why Holly ought not to sit on the chair before examination for fibre transfer!

Focusing on  BPA, we were able to show that distribution and pattern can often explain exactly how the blood has ‘appeared’ at the scene and what has gone on, while also highlighting that thorough microscopic screening can identify even the tiniest traces of blood on  an item. Similarly, locating, recovering and examining marks and trace evidence is fundamental to forensic investigation. Even the most expert criminal is likely to leave some evidence behind. Footprints, tools, weapons, and fingerprints all provide vital clues – and, in our experience, often the most elusive and conclusive proof to convict major crime suspects.

Our second appearance was to demonstrate fire investigation, looking at the differences between accidental ignition and arson and what a Crime Scene Investigator would look for and collect at a scene.

Fire impacts upon everything in its path and therefore poses some difficult challenges for forensic scientists. Fires often start accidentally as a result of faulty appliances or unattended candles. However, where arson is suspected investigators will search specifically for evidence of flammable liquids (or “accelerants”).

With the fantastic support of the Surrey Fire & Rescue Service we laid two fires – one with and one without petrol, but using similar material for burning. The development patterns were obvious and would have helped to establish the origin and cause of the fire, had it been a real scene. In this case, however, we were happy to share the spotlight with the Fire Rescue team’s fire-trained dog, Tilly, who was as attuned to the nuances of the accelerants as the drugs or explosives animals that we see deployed more often.

Naturally, a balance has to be found between us wanting to show the analytical science and using what works best for television, so, unfortunately, we weren’t able to explore the spectrographs that we also provided – that would have shown that one fire was set with paraffin (a GCMS fingerprint of paraffin looks like an umbrella) – nor gas headspace chromatography.

Working regularly with This Morning has been hugely enjoyable, nonetheless.  Maybe we can find a way to get some air time for some pure science next time…

Co-authored by Tracy Alexander.

Jan 21

Where’s the value in burger fraud?

HorsesInvestigations are under way to try to find out how beefburgers on sale in UK and Irish supermarkets became contaminated with horsemeat.

When asked about the issue, Michael Walker, Science and Food Law Consultant with LGC, said, “In the UK the presence of horsemeat and, for some, pigmeat in beefburgers, is objectionable and emphasises the need for vigilance in monitoring the supply chain with sound analytical testing.

It is possible that human error diverted the supply of horsemeat from legitimate producers to the plants that seem to be implicated. In some countries, of course, horsemeat is a legitimate part of the supply chain and traditional recipes for salami and salami-type products may include meats from animals such as wild boar, horse and donkey. 

However, it is also possible that fraud – including cheaper meats to ‘bulk up’ the main constituent meat product – is involved.

Thankfully there do not appear to be any health implications here but the incident emphasises the need for vigilance. A relatively large survey for horsemeat in salami was carried out in 2003 with essentially negative findings but this sort of thing crops up from time to time.

Regarding the presence of pigmeat in beefburgers, the FSAI have suggested that it may be cross contamination from handling pork meat in the same plant. This is credible, especially if the levels found were low but is worrying in that cleaning and separation are basic to good hygiene and should have worked to prevent cross contamination.

In the UK, it is an offence under Sections 14 and 15 of the Food Safety Act 1990 to sell food that is not of the nature, substance or quality demanded by the consumer, or to falsely or misleadingly describe or present food. Consumers do not expect horsemeat in beefburgers and for those who wish to avoid pigmeat the description and labelling of the food must be accurate and honest to allow them to do so.

DNA testing for meat species is a well established technique and I am sure the FSAI laboratories carried out stringent quality control of their testing to ensure accurate results.

Although objectionable to many, the presence of horsemeat carries no safety implications provided the proper hygiene and safety checks took place prior to and after slaughter. However if fraud was involved there is a risk that those checks were ignored, resulting in unknown possibilities of microbiological and chemical hazards such as food poisoning and veterinary drug residues.

Lastly, there is a section of the population that is at real risk from undeclared and fraudulent switching of food ingredients in the supply chain. People with allergies depend on accurate and honest labelling to protect them and there have been fatalities when, for example, peanuts have been used to substitute for more expensive nuts in food products.”

 

According to the BBC report, “A total of 27 burger products were analysed, with 10 of them containing traces of horse DNA and 23 containing pig DNA…. Horsemeat accounted for approximately 29% of the meat content in one sample from Tesco….”

Irish food safety officials, FSAI, who carried out tests two months ago, said the products had been stocked by a number of chains, including Tesco and Icelandstores in the UK.

They said “There is no risk to consumer health… we have evaluated the potential risks, such as the presence of bacteria or medicinal residues. Firstly, if bacteria were present, they would be killed by cooking and as these burgers are cooked before they are eaten, there is no risk to consumer health. Secondly, the burgers that tested positive for horse DNA were then tested for the presence of phenylbutazone, a commonly used medicine in horses that is not allowed in the food chain, and all of the results were negative.”

Tesco said it was “working… to ensure it does not happen again”.

Nov 01

What’s new in measurement?

At LGC we love measurement science, but realise it’s not to everyone’s tastes! So we’ve developed Catalyst, a newsletter that takes the vast discipline of metrology and makes it more digestible.

In this issue discover how LGC is applying leading-edge science and the development of improved measurement procedures to underpin some of the most challenging and important measurements made in the UK.

Also, are you baffled by reference materials? ‘What’s in a number?’ on page 4 sheds light on why reference materials are important and demonstrates real-life applications for using reference materials.

Are you making your measurements matter? See pages 6 and 7 to find out how to get help from the National Measurement System, including training, access to guidance documents and calibration services.

Uncertain about uncertainty? Our bite-size article on page 9 will add some certainty.

We hope you find this newsletter useful. Please let us know content you’d like featured and we’ll do our best to accommodate.

Oct 12

Selenium supplements

There are many challenges facing supplement manufacturers to ensure the safe and responsible developement of  food supplements.

Selenium, in particular, has become increasingly recognised in recent years and an essential mineral  to human health, and studies suggest that fortified foods can offer potential health benefits. However, there is a fine balance between toxic and beneficial effects of selenium.

This case study describes how LGC researchers are using their expertise in selenium analysis to develop a range of reference materials to ensure food and supplement manufacturers can verify the composition and safety of their products.

 

Aug 21

We may be exposed to dioxins but how can we maintain Standards?

Sometimes it seems that dioxins are never really that far from the news. Perhaps it started in 1976, when an accident at a chemical manufacturing plant in Italy (in what became known as the Seveso disaster) gave rise to standardised industry regulations known as Seveso II Directive. This was followed in 1983, when a dioxin scare saw the Missouri town of Times Beach completely evacuated. More recently, we have seen scares when food products (often meat, dairy and fish) have become contaminated (see examples of news stories here and here), and earlier this month the US announced a four-year, $43m joint project with Vietnam to remove dioxins - linked to cancer, birth defects and other disabilities – from the site of a former US air base in central Vietnam.

Between 1962 and 1971, the US military dropped some 75m litres of the defoliant ‘Agent Orange’ – material consisting of herbicides contaminated with dioxin and mixed with jet fuel – on what was then South Vietnam, damaging about 2m hectares  of forest.

Although the site of the air base is now closed to the public, until it was sealed off five years ago, locals still used water and fished in its contaminated lakes and wetlands, where dioxins have seeped into soil and sediment over the decades.

But, Vietnam’s legacy notwithstanding, what is the risk from dioxins? Dioxins are mainly by-products of industrial processes (smelting, chlorine bleaching, manufacturing of some herbicides and pesticides) but can also result from natural processes, such as volcanic eruptions and forest fires. It is possible that dioxins and polychlorinated biphenyls (PCBs) can get into our food from the environment, and long-term exposure can cause cancer or damage to the immune and reproductive systems.

As the WHO points out, “due to the omnipresence of dioxins, all people have background exposure, which is not expected to affect human health. However, due to the highly toxic potential of this class of compounds, efforts need to be undertaken to reduce current background exposure”.

Of course, this means that laboratories testing products for the presence of dioxins and other contaminants require reference standards and materials to ensure the accuracy of results, and the validity of their testing methods.

LGC Standards has a comprehensive range of reference materials for such analysis of dioxins, PCBs and related environmental contaminants. The range includes a wide portfolio of isotope labelled standards, as well as unlabelled standards, and matrix materials, and has recently been complemented by the addition of dioxin and dioxin-like reference samples from BioDetection Systems (BDS).

 

If you would like further info on any of LGC Standards environmental contaminants range, please contact us at: askus@lgcstandards.com.

Jul 30

Faster, Higher, Stronger…Cleaner

Many sportsmen and women heading for this summer’s major sports events will undergo urine and/or blood tests to ensure that they have not been taking performance-enhancing substances such as steroids, stimulants etc.

Football’s UEFA European Championships has just been declared “drug-free”, following “All 31 matches [which were] subject to controls, while teams and players [were] subject to no-notice testing in rest periods between matches”. 

At the London Olympics, meanwhile, “up to 6,250 samples [will be taken] during the … Games. One in every two Olympic athletes will be tested, including all medalists.

There have been cases in the past where athletes have fallen foul of anti-doping tests, without having knowingly taken a performance enhancing substance. Some of these have been attributed to nutritional supplements that have been inadvertently contaminated with banned substances, which do not appear on the product label. Research has shown that anywhere between 10-25 % of non-certified supplement products could be contaminated with a steroid or stimulant.

The Informed-Sport supplement certification programme (www.informed-sport.com) was set up in 2008 by LGC’s HFL Sport Science, a world leading sports anti-doping lab, based in Cambridgeshire, UK and Lexington, USA. The Informed-Sport programme is designed to help reputable sports nutrition manufacturers ensure that their products are not inadvertently contaminated with banned substances, and to help athletes make an ‘Informed-Choice’ when choosing a sports product. Products registered with Informed-Sport undergo a rigorous acceptance process including an audit of the quality control systems at the production facility and label review, as well as products testing. Once registered on the programme, manufacturers send samples of every batch into the HFL lab and have them tested for a broad range of banned substances. Once cleared, through rigorous testing, the product is able to display the Informed-Sport logo on pack.

Informed-Sport was set up in consultation with sports anti doping organisations and members of the supplement industry. All testing of supplement products is performed at HFL’s labs. The testing methods used are accredited to the ISO 17025 standard, a key part of any sports anti-doping testing. Ultimately, the programme helps to reduce the potential for failed drugs tests in sport, due to inadvertent contamination of sports supplements.

Athletes that see the Informed-Sport logo are re-assured that the product has been made to the highest quality standards and has been screened for banned substances.

Informed-Sport works closely with a number of sporting authorities around the world, providing an educational platform via its website, as well as expert advice and educational materials on the importance of finding trusted products.

If all athletes this summer stick to trusted supplements, then all that stands between them and victory is the hours and hours of training, PMA, luck of the draw, rub of the green, weather and the form of their opponents.  Good luck to all!

Jul 23

Size Matters! Solving nanoparticle toxicity challenges

You may be surprised to learn that nanoparticles are already incorporated in over 1300 commercial products from food and consumer products to electronics, automotive and medical products. With the 2012 Olympic Games fast approaching, news of how nanotechnology can revolutionise sport has hit the headlines, raising questions as to where the line should be drawn between sporting talent and technology. Nanomaterials, for example, offer the ability to produce lighter, stronger or more streamlined athletic clothing and equipment – including bicycles and running spikes reinforced with carbon nanotubes, sunglasses with a protective and anti-reflective polymer ‘nanofilm’, and tennis rackets containing silicon dioxide nanoparticles in the strings to increase strength and optimise control.  Our athletes are now kitted out in sportswear that not only looks great but also performs in a different league.

So what makes nanotechnology beneficial for technological innovation? It is down to the unique mechanical, thermal, and catalytic properties that materials develop when structured at the nanoscale. But on the flip side, it is these unique properties that make it difficult to predict the effects of nanomaterials on human health when based on known risks for macro-sized particles with the same chemical composition.

At LGC we have several researchers who specialise in understanding the toxic effect of nanoparticles. They are carrying out unique research to develop methods to enable a better understanding of the potential harmful or toxic effects of nanoparticles in foods and consumer products, as well as developing tools to measure the toxicity of nanoparticles.

I met with Dr Heidi Goenage-Infante and Dr Damian Marshall, both Principal Scientists at LGC, to find out how their research aims to improve nanoparticle toxicity measurement. In an article written for IUPAC Chemistry International, I explain how Dr Goenage-Infante’s and Dr Marshall’s research, funded by the UK National Measurement System, shows promise to improve and standardise nanoparticle toxicity measurements.

Full article in Chemistry International.

Jul 05

Helping football shirts avoid an own goal

LGC’s Consumer Protection team provides advice and analytical services on consumer products and materials to show compliance with chemical requirements contained in regulations and standards.

With increasing responsibilities on manufacturers and suppliers to comply with chemical legislation, there is a need for independent testing to demonstrate that requirements have been met.

Why is this type of testing so important? A timely example has been highlighted by The European Consumers’ Organisation (BEUC) whose members have claimed that “9 official EURO 2012 shirts…were found to have worrying levels of chemical content. Lead, a heavy metal, is found in 6 out of 9 tested shirts. In kits from Spain and Germany, lead exceeds recommended levels for children products.”

Exposure to lead can harm kidneys, heart, bones and the reproductive and nervous systems.

Nonylphenol was claimed to be found in 2 of the shirts tested.  Not only can Nonylphenol affect hormonal balance (it has been found to be a weak oestrogen in both laboratory animals and fish) but it is also banned from wastewater due to its harmful effects on the environment. 

As Monique Goyens, Director General of BEUC, said, “It is inexplicable that heavy metals are used in mass consumer products….Our members’ test results are a sad reminder that Europe’s chemicals legislation is unfit for the purpose of banning dangerous substances from consumer products. The upcoming review of REACH, Europe’s chemicals legislation, …gives the EU ample opportunity to be on the offensive against harmful chemicals.”
 
Simply put, chemical compounds such as these should be controlled at all points of the manufacture and supply chain.  With regards to LGC’s own consumer safety tests, our team has extensive experience in the analysis of cosmetics, toys and childcare products. This experience is derived from active participation on relevant EC working parties, as well as British, European and international standardisation committees.

Our involvement in these key decision-making bodies and our expertise in the development and validation of analytical test methods ensure that LGC is well-placed to help companies at different points in the supply chain.

We support a wide range of product types, including healthcare, childcare, personal and home care, and provide expert analysis and advice to help companies meet regulatory requirements, investigate factors in product failures and conduct product de-formulation.  For more information please check our website.

Jun 12

Football – the beautiful game…made even more so by science

Love football or hate it, unless you’ve been hibernating the last few days, you will undoubtedly be aware that England got their Euro 2012 campaign up underway last night when they took on France in Donetsk.

It was certainly a mixed game, with varied post-match commentary:
It is a decent result and a decent performance at times” says a BBC Sport tactical expert.
For all the ball, we did not work the goalkeeper and never hit the target with the chances we had” says a BBC Sport pundit.
France should have done more, because they dominated the game with possession” says a BBC Radio 5 live pundit.

However, for all the shouting at the TV, cheers, groans and in-depth analysis you can’t get away from the fact that nowadays science and measurement have a huge impact on the world’s most popular sport.

Coaches rely on science for monitoring player performance, ensuring correct nutrition for peak performance, and understanding the effect of stress on fitness and injury recovery. Specially placed cameras around a football pitch and complex computers enable in-depth analysis of player performance. Player speed, distances covered, areas where they are most active, tackles made, plus loads of other stats, can all be measured during a match. Analysis on BBC’s Academy states that Wayne Rooney can cover around 11.82km during a match!

With technology producing stats like this, we can spend hours digesting our team’s or country’s performance. Statistics from last night’s game demonstrate that France had seven shots on target to England’s one, James Milner covered a distance of 11.8km and Steven Gerrard made the most tackles.

Whilst fascinating, where would football be without some good ol’ fashioned measurement? Football pitches are still measured in yards, but interestingly there is no standard length. The length of a pitch must be between 100 yards and 130 yards and the width not less than 50 yards and not more than 100 yards. Penalties are taken 12 yards from the goal and the goal is eight feet high and eight yards wide. The standard ball size has a circumference of 69 cm ± 0.5 cm.

And what is the most important measurement in football? The pint, of course! Pubs are only allowed to sell drinks in measures of a half pint, pint or half pint multiples. This is enforced by the Weights and Measurement Act. So this Friday, when you tuck into your beverage watching England take on Sweden, you can be sure you are not being sold a short measure.

May 18

A trip to our scientific past – some nostalgic, funny & fascinating pics!

LGC has been around since 1842 so we have a treasure trove of photos, reviews, journals and handwritten calibration charts in beautiful copperplate, all hidden away in our archives. I’ve had a rummage around and dug up some fascinating pics, so I thought I’d share them with you. What better way to spend a Friday afternoon?! Click on any image for a slideshow.

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