Jul 01

Discover what inorganic mass spectrometry can do

Inorganic mass spectrometry has a wide range of potential applications, from reference material development to nanoparticle analysis or pharmaceutical testing, as will be showcased by LGC scientists at the 18th Biennial National Atomic Spectroscopy Symposium (BNASS) on 4 to 6 July 2016.

BNASS is the biennial meeting of the RSC Atomic Spectroscopy Group and provides a forum to encourage the exchange of ideas and knowledge in analytical atomic spectroscopy. The conference has been running for over 30 years and has an international reputation for both the quality of the science presented and the unique style of the symposium. Our scientists will be giving 2 presentations and presenting 3 posters, details of which can be found below.

Heidi Goenaga-Infante working in the lab

Keynote lecture: ICP-MS hyphenations for the characterisation of nanomaterials: from size-based speciation to counting, Heidi Goenaga-Infante (pictured, Session: Single particle/nano particle applications, 6 July)

Nanomaterials are being used in an ever-growing number of products (currently over 1300) but their potential impact on human health and the environment is not yet well understood. To support and drive legislation there is a need for appropriate measurement capabilities to ensure their safety and protect consumer health. This keynote lecture will cover the role of inorganic mass spectrometry (ICP-MS) and hyphenated technologies (FFF) for the characterisation of nanomaterials.


Lecture: Developing reference methods and certified reference materials for challenging biological samples – a whole blood material to support Cr and Co analysis for metal-on-metal hip replacement patients, Sarah Hill (Session: Bio-analytical applications, 5 July)

A fundamental part of LGC’s role as the UK’s designated measurement institute for chemical and biological measurements is the production of reference materials. In this talk the challenges associated with method development and production of a whole blood certified reference material (CRM) for cobalt (Co) and chromium (Cr) using inorganic mass spectrometry (ICP-MS) will be discussed. This Co/Cr CRM, to be released later in 2016, will support hospitals in monitoring levels of metal ions in the blood stream of metal-on-metal hip replacement patients to ensure accurate and early diagnosis of joint failure.


Posters to look out for:

Elemental impurities testing to ICH Q3D: Practical challenges

Recent European regulation changes require the testing of all new pharmaceutical drug products and excipients for metal impurities (ICH Q3D, effective from this month) with similar legislation coming in to force in the USA next year (USP 232/233). Sarah James will present a poster on our specialist capabilities and services in this area and you can find out more on our website.

LA-ICP-MS elemental bio-imaging: double IDMS quantification and uncertainty estimation

The accumulation of iron in the brain is associated with the progression of Alzheimer’s. David Douglas will present the first potential reference method for determining iron in brain tissue. This work will ultimately provide validation for non-invasive imaging techniques such as MRI and PET scans. This will enable earlier disease diagnosis, leading to quicker administration of drugs to slow disease progression and an overall improvement in patient care. Read our recent JAAS paper to find out more.

The use of QQQ-ICPMS technology for interference-free measurement of 129-I: Improving selectivity for reference value assignment using isotope dilution analysis

Iodine is an essential element naturally found in some foods and is of particular importance for pregnant women and infants as it plays a critical role in brain development. Sarah Hill will present the use of a novel inorganic mass spectrometry technique (QQQ-ICP-MS) to accurately quantify iodine in infant formula milk, a method suitable for the certification of reference materials.

Strategies for size-specific isotope dilution quantification of silica nanoparticles using FFF-ICP-MS

To support the characterisation of nanoparticles, there is a need for the development of reference methods and materials. Susana Nunez will present a novel approach to accurately quantify silicon nanoparticles in a complex sample using a hyphenated inorganic mass spectrometry technique (FFF-ICP-MS). This approach has potential for the characterisation of nanoparticle reference materials in the future.



For further information on when the Co/Cr CRM will be available, and for other reference material information, please contact our sales team.

LGC, the UK’s Designated Measurement Institute for chemical and bio-measurement

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