Category Archive: Bioanalysis

Oct 14

Standards to foster innovation: the NML at the forefront

Thousands of experts worldwide give significant time and effort each year to develop the voluntary technical agreements that are published as international standards. These standards contain expert knowledge and best practice and have a wide range of applications – from how to produce reference materials, to state-of-the-art methods to monitor heavy metals in air, to …

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Sep 08

The MIC: A Misunderstood Animal?

I read recently a paper which studied ‘relevance’ of MIC data against clinical outcomes. The conclusion of the paper as that there is no link between MIC data and clinical outcomes in the case of vancomycin for left sided endocarditis. While there may be some merit in the claim that the MIC is relied on …

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May 26

Accurate MIC endpoints with automation

LGC-Anti-infective-drug-development_services

LGC’s drug development team regularly assess new methods to refine and strengthen our existing analytical services across all disciplines.   An old-school stalwart of microbiology testing, minimum inhibitory concentration (MIC) testing identifies the lowest concentration of a substance that prevents visible growth of a bacterial strain.   The MIC is the bacteria’s tipping point and …

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Sep 21

Alzheimer’s disease diagnosis: the need for speed

Every three seconds there is a new case of dementia somewhere in the world. Dementia is the broad term for brain disorders that affect memory, thinking, behaviour and emotion, and is a debilitating and currently incurable condition that affects 10.5 million people in Europe and over 46 million people globally. With an aging population this …

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Mar 24

Tuberculosis: still stuck in Victorian times?

Surprisingly for what many consider to be a long-dead Victorian disease, tuberculosis (TB) remains a problem in the UK and the message of this World TB Day (24 March 2016) “Unite to End TB” is still relevant. The number of cases within the UK has risen over the last 30 years and, although numbers are now …

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Jan 22

Little to LARGE: LC-MS/MS peptide method development for small molecule specialists

The development of LC-MS/MS methods for the quantitation of large molecules within biological matrices can help to overcome some of the challenges associated with immunoassay-based analyses. For example, the need to raise new antibodies against novel analytes, poor specificity due to cross reactivity with similar compounds, and for radioimmunoassays the additional safety considerations. LC-MS/MS method …

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Jul 10

Supercharging reagents – revving up peptide LC-MS analyses

Over the past 5 years, LC-MS has (arguably) become the technique of choice to quantify peptides in biological matrices. The benefits of using LC-MS as a quantitative technique are significant, however, there is one drawback – low sensitivity. The acquisition of multiple numbers of charge states for peptides in the MS source can result in …

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May 28

Anti-microbial resistance: the importance of measurement accuracy

Imagine a world in which your morning shave or an afternoon pottering in the garden poses a major risk to your life. Or the medical breakthroughs that have led to organ transplantation and cancer treatment are no longer viable and no treatment exists. This could be a reality if the “ticking time bomb” of anti-microbial …

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May 01

Metabolism of therapeutic peptides

Peptide and protein based drugs are significantly more complicated to work with than small molecules, and as yet do not have specific guidelines for their development with regards to in-vivo metabolites. The analysis of metabolites from small molecule drugs is defined by the FDA in the metabolites in safety testing guidelines (MIST, 2008). Currently, analytical …

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